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July 10, 2015


Ultrafast Laser Microsurgery Probe for Scar Treatment in Vocal Folds

Onur Ferhanoğlu
Istanbul Technical University, Turkey

Date: July 10, 2015 (Friday)
Time: 15:40
Place: Physics Seminar Room SA 240

HOST: F. Ömer İlday


Ultrafast laser microsurgery has emerged as a remarkable technique for precise ablation of tissues with minimal damage to its surroundings. The combination of ultrafast laser microsurgery with nonlinear optical imaging modalities provides microscopic visualization to guide laser incision. A clinical endoscope capable of image-guided ultrafast laser microsurgery will provide physicians a means for cellular-level microsurgery with the highest precision.

In this talk, I will present a miniaturized fiber-coupled probe for image-guided microsurgery, towards future realization as a clinical endoscope. This development includes delivery of high-energy femtosecond laser pulses through air-core photonic bandgap fiber, laser beam scanning via a piezo-scanning tube, focusing and collection of light using aspheric lenses. Its inline optical architecture provides easy alignment and substantial size reduction to 5 mm diameter as compared to previous MEMS-scanning devices, while realizing improved lateral and axial resolution.

The treatment of scarred vocal folds has been identified as a novel application. Towards developing a new method for restoring tissue viscoelasticity in scarred vocal folds, a method was proposed to localize biomaterials within subepithelial voids ablated using ultrafast laser pulses. The clinical implementation of this method necessitates the quantification of the laser parameters for ablating scarred tissue. I will also present a comprehensive study of these parameters including ablation threshold and bubble lifetime in healthy and scarred tissues.